Acetyl L-Carnitine or L-Carnitine ? Whats Best ?

Acetyl L-Carnitine or L-Carnitine ? Whats Best ?

Acetyl L-Carnitine or L-Carnitine? Do we get asked this every day on what is the best form of L-Carnitine to take?

First, we need to clear up some “Bro-Science ” some companies like to spin without Robust Clinical Evidence.

Fact Number 1 – Acetyl L-Carnitine is a form of L-Carnitine it just has an Acetyl Molecule attached ( Acetylation ) by having the Acetyl molecule attached it allows the L-Carnitine molecule to By Pass the Blood-Brain Barrier because of the Acetyl molecule has an active hydrogen atom which allows the Acetyl molecule to produce specific ester called an Acetic anhydride .

Fact Number 2 – Acetyl L-Carnitine and L-Carnitine cannot Burn fat by themselves! But L-Carnitine can improve the fat cells ability to produce a higher quantity of the Signalling molecule ( Adipokine) called Adiponectin this has been shown to Improve both glucose and Fat Metabolism through the Mitochondria.

Fact Number 3 – L-Carnitine can only help the transport of adipocytes ( Fat ) to the Mitochondria from the bioavailable sources of fat in the blood and Stores Fat, but the process of Oxidation requires a steady flow of Oxygen ( Aerobic Activity ) this mean exercise under the Anaerobic threshold ( so Weight Training is Anaerobic or Without Oxygen ) so Walking , Cycling or Cardio   ! so for all the ” Anti Cardio Club ” people out there if you want to make the most of the Acetyl L-Carnitine or L-Carnitine supplement ! best you adopt the Suppkings Nutrition #cardioking approach.

Fact Number 4 – The energy source Oxidation causes is one of two types, in the process of Oxidation in the #cardioking Aerobic environment remembering the Mitrochridia needs a constant supply of oxygen to use Carnitine to improve what called the Carnitine Shuttle but even with carnitine the body MUST supply the mitochondria two specific enzymes to bring the Fat into the cell, without these two enzymes and the presence of oxygen Fat Oxidation can occur . One of the Enzymes are called Palmitoyltransferase I ( CPTI ) once this enzyme can bring fatty acids into the muscle cell from either the Blood or Stored Fat, once inside the Mitochondria the fatty acids can then be broken down through multiple pathways including beta-oxidation, tricarboxylic acid cycle (TCA) and then through oxidation process its self to produce ATP ( Adenosine Triphosphate ) or the other Energy so excess energy can become Heat ! .


So I guess the main points to know is Acetyl L-Carnitine helps boost the Circulating levels of L-Carnitine through the attachment of the Acetyl Molecule, while the Acetyl contribution can assist the brain’s ability to produce AcetylCholine which is the Neurotransmitter used by the brain to transfer neurons to activate the body’s nervous system, which helps with activating muscle ect and general muscle activations caused by the brain triggering this .

L-Carnitine which includes Acetyl L-Carnitine can improve the Carnitine Shuttle effect but only with Aerobic activity! So NO #Anti Cardio Club if you want to get the very best out of the Acetyl L-Carnitine or L-Carnitine product! it’s only going to work in an Aerobic state !! #Cardioking

How to Take L-Carnitine or Acetyl L-Carnitine?

L-Carnitine comes in many forms so depending on the form of L-Carnitine your taking it does vary so to make it easy based on Clinical Evidence we would suggest the following :

  • GPLC ( Glycine Propionyl L-Carnitine ) 1,000-4,000mg daily in divided dosages. ( Away from food 1 hour either side )
  • L-Carnitine, L-Carnitine Tartrate – 1,000-4,000mg daily in divided dosages ( Away from food 1 hour either side )
  • ALCAR or Acetyl L-Carnitine – 700mg – 2,500mg daily in divided dosages ( Away from food 1 hour either side )

Real Clinical references

Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy.

Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue.

L-Carnitine treatment reduces the severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial.

L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.

Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans.